What's your favorite devastating page or panel?

My favorite is from Allison Bechdel's autobiography about her relationship with her mother, Are You My Mother. Here it is For context, that's Allison as a young girl, with her mother, who was usually emotionally detached, asking if her daughter loves her. It's such a brilliant use of the medium that has so many layers. It's one of the only full page panels in the book, giving it extra impact since it has room to breathe. There's three streams of dialogue (the tv, the conversation, the captions), with a high camera angel to give the impression that the child has the power in this instance, and to make the reader feel off kilter. The expression on Allison's face is deadpan, she doesn't know how to react to such an alien situation. All of it combines to just...wreck me. That poor kid.